By Elizabeth A. Montgomery MD, Lysandra Voltaggio MD
Gastrointestinal mucosal biopsies are an lively a part of the pathologist’s day and feature elevated some time past few years as endoscopic screening has turn into extra standard. This new full-color moment version of Biopsy Interpretation of the Gastrointestinal Tract Mucosa has been elevated into concise, finished volumes to provide extra whole assurance of either non-neoplastic and neoplastic entities. just like the different books within the Biopsy Interpretation Series, those volumes are sensible references for pathologists to take advantage of while making diagnostic judgements in response to biopsy specimens.
Volume 2 of this moment variation specializes in interpretation of neoplastic gastrointestinal mucosal biopsies. insurance is geared to day-by-day perform and contains mucosal biopsies from the esophagus, belly, small gut, huge gut, and anus. A better half web site will comprise all the three hundred print illustrations plus an extra 750 e-figures.
Volume 1 makes a speciality of non-neoplastic biopsies and released in November 2011.
Read or Download Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic (Biopsy Interpretation Series) PDF
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Additional info for Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic (Biopsy Interpretation Series)
Cellular stratification, nuclear irregularities, dystrophic goblet cells, and loss of polarity may also be seen. Lomo et al. showed that, by immunohistochemistry, this type of epithelium demonstrates a significantly elevated basal crypt MIB1 proliferation rate and prominent P53 positivity compared with nondysplastic BE (e-Figs. 130). 05) (44). 31 Basal crypt dysplasia (BCD). This low-power photomicrograph shows BCD with deep cytologic abnormalities but surface maturation. 32 Basal crypt dysplasia.
Both of these latter situations are associated with ulcers. Nuclei may have either delicately clumped, dark heterochromatin and inconspicuous nucleoli, or prominent, irregular nuclei with irregularly clumped chromatin and irregular nucleoli. 19 Barrett esophagus, high-grade dysplasia. This low power magnification shows total lack of surface maturation with crowding of cytologically abnormal glands. extend to the surface. Loss of nuclear polarity is seen in high-grade dysplasia. Mitoses are readily identifiable.
These cases show numerous, tiny glands that appear bland (but hyperchromatic) at low magnification, but that display nuclear alterations when examined at high power. Loss of nuclear polarity is evident here. patients are best served with close follow-up. We have seen a rare case of high-grade dysplasia in a patient taking colchicine for the treatment of gout. 154). 34 Lateral surface extension of dysplasia. Occasionally, dysplasia extends laterally on the surface of nonneoplastic cardiac or cadiac–oxyntic glands, as in this case.