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46. Cummings BJ, Keane TJ, O’Sullivan B, et al. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Rad Onc Biol Phys 1991; 21(5):115–125. 47. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups.
Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979 Jan; 5(1):85–91. 28. Laver JH, Barredo JC, Amylon M, et al. Effects of cranial radiation in children with high risk T cell acute lymphoblastic leukemia: a Pediatric Oncology Group report. Leukemia 2000; 14(3):369–373. 29. Dubey AK, Recht A, Come S, et al. Why and how to combine chemotherapy and radiation therapy in breast cancer patients. Recent Results Cancer Res 1998; 152:247–254.
2. Effect of Scheduling of 5-FU on Radiosensitization The studies have also suggested the “scheduling” requirements for obtaining radiosensitization induced by 5-FU, and that 5-FU must be present for at least 24 h after each (and every) radiation fraction to achieve maximum radiosensitization. Investigators also tried to determine the optimum duration of the infusion. Moertel et al. studied CI up to 24 h in duration and found no significant difference in toxicity vs bolus therapy (43). On the other hand, Seifert et al.