By Keith D. Lindor, Jayant A. Talwalkar
Over the last twenty years, there was a gentle raise in wisdom linked to the scientific manifestations of cholestatic liver illness. in line with those medical occasions, this booklet presents priceless and well timed details at the ever-expanding topic of cholestatic liver ailment. It offers clinical updates from prime specialists which relate to the medical review and administration of cholestatic liver problems.
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Additional info for Cholestatic Liver Disease (Clinical Gastroenterology)
On liver biopsy, the characteristic finding is canalicular dilation with bile casts, predominantly occurring in acinar oz ne 3 (centrllobular region). There is typically Chapter 2 / Drug-Induced Cholestasis 29 little or no inflammation or necrosis (4,13). The classic drugs that result in cholestasis without hepatitis are the steroid hormones such as oral contraceptives (30). Cases of azathioprine (31), anabolic steroid (32), erythromycin (33), cyclosporine A (34), and tamoxifen (3)-induced cholestasis have also been reported.
85. Bergasa NV, Alling DW, Talbot TL, et al. Effects of naloxone infusions in patients with the pruritus of cholestasis. A double-blind, randomized, controlled trial. Ann Intern Med 1995; 123: 161-167. 86. Wolfhagen R F , Sternieri E, oH p WC, Vitale G, Bertolotti M, and Van Buuren R H . Oral naltrexone treatment for cholestatic pruritus: a double-blind, placebocontrolled study. Gastroenterology 1997; 113: 12641- 269. 87. eL vy C and iL ndor D K . Management of osteoporosis, fat-soluble vitamin deficiencies, and hyperlipidemia in primary biliary cirrhosis.
J Pediatr Gastroenterol Nutr 2005; 14 : 64 9-74 3. 83. O'Brien CB, Shields DS, Saul SH, and Reddy R K . Drug-induced vanishing bile duct syndrome: response to ursodiol. Am J Gastroenterol1996; 91: 1456-1- 54 7. 84. LJ Phenobarbital effects in cholestatic liver diseases. Ann Intern Med 1975; 82: 310-317. 85. Bergasa NV, Alling DW, Talbot TL, et al. Effects of naloxone infusions in patients with the pruritus of cholestasis. A double-blind, randomized, controlled trial. Ann Intern Med 1995; 123: 161-167.