Contrast Media in Practice by H. J. Maurer, W. Clauss, T. Gulbrandsen, P. Dawson (auth.),

By H. J. Maurer, W. Clauss, T. Gulbrandsen, P. Dawson (auth.), Dr. Peter Dawson, Dr. Wolfram Clauß (eds.)

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Aufl. Ecomed, Landsberg 42. Press WR et al (1989) Tolerance to iotrolan after subarachnoid injection in animals. Fortschr Geb Rontgenstr Nuklearmed 128: 126-133 43. Scherberich JE et al (1991) Unerwtinschte Kontrastmittelwirkungen an der Niere. In: Peters PE, Zeitler E (eds) Rontgenkontrastmittel. Springer, Berlin Heidelberg New York, pp 65-69 44. SchObel C, Gunzel P (1984) Systemische Vertraglichkeitsprufungen bei wiederholter Verabreichung - subakute und chronische Toxizitatsprufung. 3, 4. Aufl.

As a consequence of the lower hydrophilicity, iodinated hepatobiliary CM exhibit considerable plasma protein binding, which at the same time, however, seems to be important in increasing the solubility in plasma and prevents premature renal excretion. Plasma binding of iodinated hepatobiliary CM is of the order of 70%-95% and appears to be saturable (nonlinear) since binding clearly depends on the CM concentration [15, 16]. Administered intravenously, iodinated hepatobiliary CM are reversibly and nonspecifically bound to plasma proteins, and an equilibrium is established between the free, unbound CM concentration and the bound CM concentration in the blood.

Acta Radiol Suppl 355:373-378 16. Hauhgton VM et al (1977) Experimental production of arachnoiditis with watersoluble myelographic media. Radiology 123:681-685 17. Haughton VM et al (1977) Arachnoiditis following myelography with water-soluble agents. Radiology 125:731-733 18. Haughton VM et al (1978) Comparison of arachnoiditis produced by meglurnine locarmate and metrizamide myelography in an animal mdoel. Am J Roentgenol 131:129-132 19. Haughton VM, Ho KC (1980) The risk of arachnoiditis from experimental nonionic contrast media.

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