By Marco Del Chiaro, Stephan L. Haas, Richard D. Schulick
This e-book offers a close, up to date review of cystic tumors of the pancreas, with insurance of all points of prognosis and therapy (medical, endoscopic, and surgical). After establishing chapters on pathology and category, cytology, molecular biology, and epidemiology, the position of every of the suitable diagnostic equipment is thoroughly tested. The treatment-related chapters describe surgical techniques, together with minimally invasive surgical procedure, in addition to ablation modalities and chemo-radiotherapy. Thorough tips is usually supplied in particular at the administration of cystic tumors in high-risk instances and on follow-up. The authors are international opinion leaders of their box who've contributed state-of-the-art chapters, with emphasis on transparent diagnostic and healing algorithms and with quite a few aiding tables and illustrations.
Owing to the frequent use of imaging modalities, clinicians are being faced through more and more sufferers with cystic tumors of the pancreas, starting from benign cysts to metastasized malignancies. The widening spectrum of accessible diagnostic measures has ended in controversy over the alternative of additional technique of research whilst cystic alterations are encountered, and the expansion in healing concepts has equally been observed by way of significant debate over their use. in contrast background, Cystic Tumors of the Pancreas will be a necessary resource of appropriate info for either clinicians and surgeons and also will be of curiosity to radiologists, pathologists, and uncomplicated scientists.
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Additional info for Cystic Tumors of the Pancreas: Diagnosis and Treatment
2007;11(7):820–6. 9. Franko J, Cole K, Pezzi CM, Montone KT, Redmond J. Serous cystadenocarcinoma of the pancreas with 16. 17. 18. 19. 20. 21. 22. 23. 19 metachronous hepatic metastasis. Am J Clin Oncol. 2008;31(6):624–5. Le Borgne J, de Calan L, Partensky C. Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg. 1999;230(2):152–61. Ohta T, Nagakawa T, Itoh H, Fonseca L, Miyazaki I, Terada T. A case of serous cystadenoma of the pancreas with focal malignant changes.
Of course, if the features on cytology are unequivocally diagnostic of malignancy, then the diagnosis should be positive for adenocarcinoma. Cytological features associated with grades of dysplasia are as follows. 1 Low-Grade Atypia Low-Grade Dysplasia (Fig. B. C. Jhala Fig. 6 IPMN with low-grade dysplasia. Columnar mucinous epithelial cells show abundant mucinous cytoplasm and minimal nuclear atypia (Papanicolaou) Fig. 7 IPMN with intermediate-grade dysplasia. Cells show stratification of the nuclei and moderate cytological atypia with mild anisonucleosis and slight loss of polarity (Papanicolaou) cytoplasmic ratio and cytoplasmic mucin.
Abraham SC, Klimstra DS, Wilentz RE, et al. Solidpseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol. 2002;160(4):1361–9. Tanaka Y, Kato K, Notohara K, et al. Frequent betacatenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61(23):8401–4. Toll AD, Mitchell D, Yeo CJ, Hruban RH, Witkiewicz AK. Acinar cell carcinoma with a prominent intraductal growth pattern: case report with review of the literature.